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NCBI C++ ToolKit: include/algo/blast/core/blast_nalookup.h Source File

31 #ifndef ALGO_BLAST_CORE__BLAST_NTLOOKUP__H 32 #define ALGO_BLAST_CORE__BLAST_NTLOOKUP__H 56  Int4

approx_table_entries,

Int4

query_length,

109 #define NA_HITS_PER_CELL 3 289  Int4

approx_table_entries,

310  return

((lo & 0x00000003) ) |

311

((lo & 0x000000f0) >> 2) |

312

((lo & 0x00003c00) >> 4) |

313

((lo & 0x000f0000) >> 6) |

314

((lo & 0x03c00000) >> 8) |

315

((lo & 0xf0000000) >> 10);

328  return

((lo & 0x0000003f) ) |

329

((lo & 0x00000f00) >> 2) |

330

((lo & 0x0003c000) >> 4) |

331

((lo & 0x00300000) >> 6) |

332

((lo & 0xfc000000) >> 10);

346  return

((lo & 0x00000003) ) |

347

((lo & 0x000000f0) >> 2) |

348

((lo & 0x00003c00) >> 4) |

349

((lo & 0x00030000) >> 6) |

350

((lo & 0x03c00000) >> 10) |

351

((lo & 0xf0000000) >> 12) |

352

((hi & 0x0000000c) << 18);

366  return

((lo & 0x0000003f) ) |

367

((lo & 0x00000300) >> 2) |

368

((lo & 0x0003c000) >> 6) |

369

((lo & 0x00300000) >> 8) |

370

((lo & 0x0c000000) >> 12) |

371

((lo & 0xc0000000) >> 14) |

372

((hi & 0x0000000f) << 18);

386  return

((lo & 0x00000003) ) |

387

((lo & 0x000000f0) >> 2) |

388

((lo & 0x00000c00) >> 4) |

389

((lo & 0x000f0000) >> 8) |

390

((lo & 0x00c00000) >> 10) |

391

((lo & 0xf0000000) >> 14) |

392

((hi & 0x0000000c) << 16) |

393

((hi & 0x00000300) << 12);

407  return

((lo & 0x0000003f) ) |

408

((lo & 0x00000300) >> 2) |

409

((lo & 0x0000c000) >> 6) |

410

((lo & 0x00c00000) >> 12) |

411

((lo & 0x0c000000) >> 14) |

412

((hi & 0x00000003) << 14) |

413

((hi & 0x000003f0) << 12);

426  return

((lo & 0x00000003) ) |

427

((lo & 0x000000f0) >> 2) |

428

((lo & 0x00003c00) >> 4) |

429

((lo & 0x000f0000) >> 6) |

430

((lo & 0xffc00000) >> 8);

443  return

((lo & 0x0000003f) ) |

444

((lo & 0x00000f00) >> 2) |

445

((lo & 0x0003c000) >> 4) |

446

((lo & 0x00f00000) >> 6) |

447

((lo & 0xfc000000) >> 8);

461  return

((lo & 0x00000003) ) |

462

((lo & 0x000000f0) >> 2) |

463

((lo & 0x00003c00) >> 4) |

464

((lo & 0x000f0000) >> 6) |

465

((lo & 0x03c00000) >> 8) |

466

((lo & 0xf0000000) >> 10) |

467

((hi & 0x0000000c) << 20);

481  return

((lo & 0x0000003f) ) |

482

((lo & 0x00000f00) >> 2) |

483

((lo & 0x0000c000) >> 4) |

484

((lo & 0x00f00000) >> 8) |

485

((lo & 0x0c000000) >> 10) |

486

((lo & 0xc0000000) >> 12) |

487

((hi & 0x0000000f) << 20);

501  return

((lo & 0x00000003) ) |

502

((lo & 0x000000f0) >> 2) |

503

((lo & 0x00000c00) >> 4) |

504

((lo & 0x000f0000) >> 8) |

505

((lo & 0x03c00000) >> 10) |

506

((lo & 0xf0000000) >> 12) |

507

((hi & 0x0000000c) << 18) |

508

((hi & 0x00000300) << 14);

522  return

((lo & 0x0000003f) ) |

523

((lo & 0x00000300) >> 2) |

524

((lo & 0x0000c000) >> 6) |

525

((lo & 0x00f00000) >> 10) |

526

((lo & 0x0c000000) >> 12) |

527

((hi & 0x00000003) << 16) |

528

((hi & 0x000003f0) << 14);

545  switch

(template_type) {

601  Int4

* pv_counts,

Int4

words_per_bit);

668 #define NA_WORDS_PER_HASH 3 669 #define NA_OFFSETS_PER_HASH 9

Definitions used throughout BLAST.

#define NCBI_XBLAST_EXPORT

NULL operations for other cases.

Common definitions for protein and nucleotide lookup tables.

#define PV_ARRAY_TYPE

The pv_array 'native' type.

static NCBI_INLINE Int4 DiscontigIndex_11_21_Optimal(Uint8 accum)

Forms a lookup table index for the 11-of-21 optimal template in discontiguous megablast.

BlastSmallNaLookupTable * BlastSmallNaLookupTableDestruct(BlastSmallNaLookupTable *lookup)

Free a small nucleotide lookup table.

static NCBI_INLINE Int4 DiscontigIndex_11_18_Coding(Uint8 accum)

Forms a lookup table index for the 11-of-18 coding template in discontiguous megablast.

Int8 FindSparseIndex(Int8 index, PV_ARRAY_TYPE *pv_array, Int4 pv_array_bts, Int4 *pv_counts, Int4 words_per_bit)

Find an index into a sparse array using pv_array as a bit field.

Int2 FindSparseIndices(Int8 *in_array, Int8 *out_array, Int4 length, PV_ARRAY_TYPE *pv_array, Int4 pv_array_bts, Int4 *counts, Int4 elems_per_bit)

Find an index into a sparse array using pv_array as a bit field, for a batch of indices.

Int4 BlastNaLookupTableNew(BLAST_SequenceBlk *query, BlastSeqLoc *locations, BlastNaLookupTable **lut, const LookupTableOptions *opt, const QuerySetUpOptions *query_options, Int4 lut_width)

Create a new nucleotide lookup table.

ELookupTableType BlastChooseNaLookupTable(const LookupTableOptions *lookup_options, Int4 approx_table_entries, Int4 query_length, Int4 *lut_width)

choose the type of nucleotide lookup table to be used for a blast search

EDiscWordType

General types of discontiguous word templates.

BlastMBLookupTable * BlastMBLookupTableDestruct(BlastMBLookupTable *mb_lt)

Deallocate memory used by the Mega BLAST lookup table.

BlastNaHashLookupTable * BlastNaHashLookupTableDestruct(BlastNaHashLookupTable *lookup)

Free a nucleotide lookup table.

static NCBI_INLINE Int4 DiscontigIndex_11_16_Coding(Uint8 accum)

Forms a lookup table index for the 11-of-16 coding template in discontiguous megablast.

static NCBI_INLINE Int4 ComputeDiscontiguousIndex(Uint8 accum, EDiscTemplateType template_type)

Given an accumulator containing packed bases, compute the discontiguous word index specified by templ...

static NCBI_INLINE Int4 DiscontigIndex_11_18_Optimal(Uint8 accum)

Forms a lookup table index for the 11-of-18 optimal template in discontiguous megablast.

struct BlastNaLookupTable BlastNaLookupTable

The basic lookup table structure for blastn searches.

Int2 BlastMBLookupTableNew(BLAST_SequenceBlk *query, BlastSeqLoc *location, BlastMBLookupTable **mb_lt_ptr, const LookupTableOptions *lookup_options, const QuerySetUpOptions *query_options, Int4 approx_table_entries, Int4 lut_width, BlastSeqSrc *seqsrc)

Create the lookup table for Mega BLAST.

static NCBI_INLINE Int4 DiscontigIndex_12_16_Coding(Uint8 accum)

Forms a lookup table index for the 12-of-16 coding template in discontiguous megablast.

static NCBI_INLINE Int4 DiscontigIndex_12_18_Coding(Uint8 accum)

Forms a lookup table index for the 12-of-18 coding template in discontiguous megablast.

static NCBI_INLINE Int4 DiscontigIndex_12_21_Optimal(Uint8 accum)

Forms a lookup table index for the 12-of-21 optimal template in discontiguous megablast.

EDiscTemplateType

Enumeration of all discontiguous word templates; the enumerated values encode the weight,...

@ eDiscTemplate_12_18_Optimal

@ eDiscTemplate_11_18_Optimal

@ eDiscTemplateContiguous

@ eDiscTemplate_12_16_Optimal

@ eDiscTemplate_12_16_Coding

@ eDiscTemplate_11_21_Coding

@ eDiscTemplate_11_18_Coding

@ eDiscTemplate_12_21_Coding

@ eDiscTemplate_11_16_Optimal

@ eDiscTemplate_11_21_Optimal

@ eDiscTemplate_12_21_Optimal

@ eDiscTemplate_12_18_Coding

@ eDiscTemplate_11_16_Coding

static NCBI_INLINE Int4 DiscontigIndex_11_21_Coding(Uint8 accum)

Forms a lookup table index for the 11-of-21 coding template in discontiguous megablast.

Int4 BlastNaHashLookupTableNew(BLAST_SequenceBlk *query, BlastSeqLoc *locations, BlastNaHashLookupTable **lut, const LookupTableOptions *opt, const QuerySetUpOptions *query_options, BlastSeqSrc *seqsrc, Uint4 num_threads)

static NCBI_INLINE Int4 DiscontigIndex_11_16_Optimal(Uint8 accum)

Forms a lookup table index for the 11-of-16 optimal template in discontiguous megablast.

struct NaLookupBackboneCell NaLookupBackboneCell

structure defining one cell of the compacted lookup table

struct NaHashLookupBackboneCell NaHashLookupBackboneCell

Structure defining one cell of the compacted lookup table.

struct BlastNaHashLookupTable BlastNaHashLookupTable

static NCBI_INLINE Int4 DiscontigIndex_12_16_Optimal(Uint8 accum)

Forms a lookup table index for the 12-of-16 optimal template in discontiguous megablast.

#define NA_HITS_PER_CELL

maximum number of hits in one lookup table cell

Int4 BlastSmallNaLookupTableNew(BLAST_SequenceBlk *query, BlastSeqLoc *locations, BlastSmallNaLookupTable **lut, const LookupTableOptions *opt, const QuerySetUpOptions *query_options, Int4 lut_width)

Create a new small nucleotide lookup table.

static NCBI_INLINE Int4 DiscontigIndex_12_21_Coding(Uint8 accum)

Forms a lookup table index for the 12-of-21 coding template in discontiguous megablast.

static NCBI_INLINE Int4 DiscontigIndex_12_18_Optimal(Uint8 accum)

Forms a lookup table index for the 12-of-18 optimal template in discontiguous megablast.

BlastNaLookupTable * BlastNaLookupTableDestruct(BlastNaLookupTable *lookup)

Free a nucleotide lookup table.

struct BlastMBLookupTable BlastMBLookupTable

The lookup table structure used for Mega BLAST.

struct BlastSmallNaLookupTable BlastSmallNaLookupTable

Lookup table structure for blastn searches with small queries.

The structures and functions in blast_options.

ELookupTableType

Types of the lookup table.

Declaration of ADT to retrieve sequences for the BLAST engine.

static int lookup(const char *name, const struct lookup_int *table)

static const char location[]

int16_t Int2

2-byte (16-bit) signed integer

int32_t Int4

4-byte (32-bit) signed integer

uint32_t Uint4

4-byte (32-bit) unsigned integer

int64_t Int8

8-byte (64-bit) signed integer

uint64_t Uint8

8-byte (64-bit) unsigned integer

int8_t Int1

1-byte (8-bit) signed integer

Type and macro definitions from C toolkit that are not defined in C++ toolkit.

#define NCBI_INLINE

"inline" seems to work on our remaining in-house compilers (WorkShop, Compaq, ICC,...

Uint1 Boolean

bool replacment for C

Structure to hold a sequence.

The lookup table structure used for Mega BLAST.

Int4 num_words_added

Number of words added to the l.t.

Int4 lut_word_length

number of letters in a lookup table word

Int4 pv_array_bts

The exponent of 2 by which pv_array is smaller than the backbone.

BlastSeqLoc * masked_locations

masked locations, only non-NULL for soft-masking.

Int4 * next_pos2

Extra positions for the second template.

Int4 * hashtable2

Array of positions for second template.

void * scansub_callback

function for scanning subject sequences

Int4 * hashtable

Array of positions.

Int4 num_unique_pos_added

Number of positions added to the l.t.

PV_ARRAY_TYPE * pv_array

Presence vector, used for quick presence check.

Boolean stride

is lookup table created with a stride

Int8 hashsize

= 4^(lut_word_length)

EDiscTemplateType template_type

Type of the discontiguous word template.

Int4 scan_step

Step size for scanning the database.

Int4 longest_chain

Largest number of query positions for a given word.

Int4 word_length

number of exact letter matches that will trigger an ungapped extension

Boolean discontiguous

Are discontiguous words used?

Int4 * next_pos

Extra positions stored here.

void * extend_callback

function for extending hits

Boolean two_templates

Use two templates simultaneously.

EDiscTemplateType second_template_type

Type of the second discontiguous word template.

Int4 template_length

Length of the discontiguous word template.

Int4 mask

part of index to mask off, that is, top (wordsize*charsize) bits should be discarded.

Int4 * overflow

the overflow array for the compacted lookup table

Int4 longest_chain

length of the longest chain on the backbone

Int4 word_length

Length in bases of the full word match required to trigger extension.

Int4 lut_word_length

Length in bases of a word indexed by the lookup table.

Int4 offsets_size

Number of elements in the overflow array.

Int4 scan_step

number of bases between successive words

Int4 pv_array_bts

power of 2 by which to divide a word to access PV_ARRAY_TYPE element in pv array

void * hash_callback

hash function to be used for hash table

BlastSeqLoc * masked_locations

masked locations, only non-NULL for soft-masking.

NaHashLookupBackboneCell * thick_backbone

the "thick" backbone.

void * scansub_callback

function for scanning subject sequences

PV_ARRAY_TYPE * pv

Presence vector bitfield; bit positions that are set indicate that the corresponding thick backbone c...

Int4 backbone_size

number of cells in the backbone

The basic lookup table structure for blastn searches.

Int4 scan_step

number of bases between successive words

Int4 longest_chain

length of the longest chain on the backbone

Int4 * overflow

the overflow array for the compacted lookup table

Int4 mask

part of index to mask off, that is, top (wordsize*charsize) bits should be discarded.

BlastSeqLoc * masked_locations

masked locations, only non-NULL for soft-masking.

PV_ARRAY_TYPE * pv

Presence vector bitfield; bit positions that are set indicate that the corresponding thick backbone c...

Int4 lut_word_length

Length in bases of a word indexed by the lookup table.

void * scansub_callback

function for scanning subject sequences

NaLookupBackboneCell * thick_backbone

the "thick" backbone.

Int4 word_length

Length in bases of the full word match required to trigger extension.

void * extend_callback

function for extending hits

Int4 overflow_size

Number of elements in the overflow array.

Int4 backbone_size

number of cells in the backbone

Used to hold a set of positions, mostly used for filtering.

Complete type definition of Blast Sequence Source ADT.

Lookup table structure for blastn searches with small queries.

Int4 backbone_size

number of cells in the backbone

Int4 scan_step

number of bases between successive words

Int4 word_length

Length in bases of the full word match required to trigger extension.

Int4 mask

part of index to mask off, that is, top (wordsize*charsize) bits should be discarded.

Int2 * overflow

the overflow array for the compacted lookup table

void * extend_callback

function for extending hits

void * scansub_callback

function for scanning subject sequences

Int4 longest_chain

length of the longest chain on the backbone

BlastSeqLoc * masked_locations

masked locations, only non-NULL for soft-masking.

Int2 * final_backbone

backbone structure used when scanning for hits

Int4 lut_word_length

Length in bases of a word indexed by the lookup table.

Int4 overflow_size

Number of elements in the overflow array.

Options needed to construct a lookup table Also needed: query sequence and query length.

Structure defining one cell of the compacted lookup table.

Int1 num_offsets[3]

number of offsets for each word if there are fewer than 3

Uint4 words[3]

words stored under this hash value

Int4 offsets[9]

offset locations for each word

Int1 num_words

number of words stored under the same hash value

structure defining one cell of the compacted lookup table

union NaLookupBackboneCell::@8 payload

UNION that specifies either entries stored right on the backbone if fewer than NA_HITS_PER_CELL are p...

Int4 entries[3]

if the number of hits for this cell is NA_HITS_PER_CELL or less, the hits are all stored directly in ...

Int4 num_used

number of hits stored for this cell

Int4 overflow_cursor

integer offset into the overflow array where the list of hits for this cell begins

Options required for setting up the query sequence.


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