From 1st January 2023, Laboratory Investigation will be published by Elsevier. For more information visit the Elsevier website or contact the Editorial Office.
Inside the USCAP Journals29 Nov 2022
Article28 Oct 2022
Inside the USCAP Journals21 Oct 2022
Inside the USCAP Journals26 Sept 2022
Technical ReportOpen Access31 Aug 2022
For precancerous/endometrial cancer patients with fertility maintain desire, progestin resistance is the main obstacle of conservative therapy. The authors found that brusatol, as a natural compound, suppresses progestin metabolism through regulating the NRF2-TET1-AKR1C1 pathway to sensitize precancerous/endometrial cancers to progestin and relieve progestin resistance. This study indicates that progestin combined with brusatol may enhance the treatment effects and that AKR1C1 expression patterns may serve as an important biomarker of progestin resistance in endometrial cancer.
Article29 Aug 2022
Inside the USCAP Journals25 Aug 2022
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