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Showing content from http://www.informatics.jax.org/marker/MGI:1340899 below:

Chi3l1 MGI Mouse Gene Detail - MGI:1340899

Summary

• Symbol

  Chi3l1

• Name

  chitinase 3 like 1

• Synonyms

  Brp39, Chil1, Gp39

• Feature Type

  protein coding gene

• IDs

  MGI:1340899

  NCBI Gene:

  12654

• Alliance

• Transcription Start Sites

  8 TSS

Location &
Maps

more

• Sequence Map

  Chr1:134109894-134117769 bp, + strand

  From NCBI annotation of GRCm39

  
  

• Genome Browsers

• Genetic Map

  Chromosome 1, 58.15 cM

• Mapping Data

Strain

Comparison

more

• SNPs within 2kb

• Strain Annotations

  18

• RFLP

Homology

more

• Human Ortholog

  CHI3L1, chitinase 3 like 1

• Vertebrate Orthologs

  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog

  CHI3L1, chitinase 3 like 1
  

• Synonyms

  ASRT7, CGP-39, GP-39, GP39, hCGP-39, HC-gp39, HCGP-3P, YK-40, YKL-40, YKL40, YYL-40

• Links

• Chr Location

  1q32.1; chr1:203178931-203186704 (-)  GRCh38

• MGI Vertebrate Homology

• HCOP

  vertebrate homology predictions:

  CHI3L1

• Gene Tree

Human Diseases

more

• Diseases

  2 with human CHI3L1 associations

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

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• Phenotype Summary

  13

  phenotypes from 1 allele in 1 genetic background

  
  3

  phenotypes from multigenic genotypes

  
  33

  phenotype references

  
  

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue

behavior/neurological

cardiovascular system

cellular

craniofacial

digestive/alimentary system

embryo

endocrine/exocrine glands

growth/size/body

hearing/vestibular/ear

hematopoietic system

homeostasis/metabolism

integument

immune system

limbs/digits/tail

liver/biliary system

mortality/aging

muscle

nervous system

pigmentation

renal/urinary system

reproductive system

respiratory system

skeleton

taste/olfaction

neoplasm

vision/eye

• All Mutations and Alleles

• Chemically induced (other)

• Endonuclease-mediated

• Radiation induced

• Targeted

• Genomic Mutations

• Incidental Mutations

• Find Mice (IMSR)

• Comparison Matrix

Homozygous null mice show impaired OVA-induced Th2 responses with reduced splenocyte proliferation, cytokine production and IgE levels, impaired dendritic cell recruitment, higher CD4 T cell, macrophage and eosinophil apoptosis, and reduced CD4 T cell and alternatively activated macrophage numbers.

Gene Ontology
(GO)
Classifications

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• All GO Annotations

• GO References

Molecular Function

carbohydrate derivative binding

cytoskeletal protein binding

DNA binding

enzyme regulator

hydrolase

ligase

lipid binding

oxidoreductase

RNA binding

signaling receptor activity

signaling receptor binding

transcription

transferase

transporter

Biological Process

carbohydrate derivative metabolism

cell differentiation

cell population proliferation

cellular component organization

DNA-templated transcription

establishment of localization

homeostatic process

immune system process

lipid metabolic process

programmed cell death

protein metabolic process

response to stimulus

signaling

system development

Cellular Component

cell projection

cytoplasmic vesicle

cytoskeleton

cytosol

endoplasmic reticulum

endosome

extracellular region

Golgi apparatus

mitochondrion

membraneless organelle

nucleus

organelle envelope

organelle lumen

plasma membrane

protein-containing complex

synapse

vacuole

Click cells to view annotations.

Expression

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

• Blue cells = expressed in wild-type.
  Gray triangles = other expression annotations only
  (e.g. absence of expression or data from mutants).

early conceptus

embryo ectoderm

embryo endoderm

embryo mesoderm

embryo mesenchyme

extraembryonic component

alimentary system

auditory system

branchial arches

cardiovascular system

connective tissue

endocrine system

exocrine system

hemolymphoid system

integumental system

limbs

liver and biliary system

musculoskeletal system

nervous system

olfactory system

reproductive system

respiratory system

urinary system

visual system

Click cells to view annotations.

• Assay Results

• Tissues

• cDNA Data

• Literature Summary

• Other Mouse Links

Sequences &
Gene Models

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• All Sequences

• RefSeq

• UniProt

• CCDS

• Ensembl

• NCBI Gene

Protein
Information

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• UniProt

• Protein Ontology

• PDB

• InterPro Domains

  IPR029070

  Chitinase insertion domain superfamily

  IPR001223

  Glycoside hydrolase family 18, catalytic domain

• GlyGen

Other
Accession IDs

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MGD-MRK-36073, MGI:107503, MGI:2138570, MGI:7469664

References

more

• Summaries

  Developmental Gene Expression

  8

• Earliest

  J:134667

  Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7

• Latest

  J:362780

  Stephan JK, et al., Neutrophil-secreted CHI3L1 exacerbates cardiac dysfunction and inflammation after myocardial infarction. FASEB J. 2025 Mar 15;39(5):e70422

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