Inbred Strains of Mice: SWV
SWVInbr (Bc) 73. Albino:
A,c,plus unknown dilution gene. Origin: Outbred animals from Defense Research Bd. Suffield, Alberta to Cent. Animal Depot, Univ. Brit. Columbia. Inbreeding started in 1959. Develops nephrogenic diabetes insipidus with a progressive and unique kidney defect. Maint. by Bc.
CharacteristicsFemales over 8 months have a hereditary polydipsia-polyuria defect with a severe increase in water turnover and with hypotonic urine that contains no glucose, blood or protein: i.e. nephrogenic diabetes insipidus. They are vasopressin-resistant. Females also have a progressive kidney defect which, although it resembles nephronophthisis in some aspects and hypokalaemia in others, is unique. Males have a milder form of the defect at an older age and show no signs of histopathology (
Virgo and Miller, 1974). Resistant to acetazolamide-induced teratogenesis (
Hackman and Hurley 1983).
Hackman R. M. and Hurley L. S. (1983) Interaction of dietary zinc, genetic strain, and acetazolamide in teratogenesis in mice. Teratology 28, 355-368. INBRED STRAINS OF MICERetroSearch is an open source project built by @garambo | Open a GitHub Issue
Search and Browse the WWW like it's 1997 | Search results from DuckDuckGo
HTML:
3.2
| Encoding:
UTF-8
| Version:
0.7.4