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MGI - Inbred Strains: STS

Inbred Strains of Mice: STS

Inbr (A) 100. Albino:

Origin: Muhlbock, from albino mice from the Hyg. Inst. Zurich in 1955.

In contrast with five other strains, STS is resistant to mammary tumour induction by hypophysial isografts (

). No mammary tumours but lung tumours in both sexes; closely related to LIS/A and LTS/A. Leukosis 8% (

). High preference for sweet tasting substances (saccharin, sucrose, dulcin and acesulfame, averaged) (3/26) (

). Carries an incomplete proviral genome of endogenous mammary tumour virus (MMTV) on the Y chromosome (c.f. 4/10) (

). Higher proliferative response in the mixed lymphocyte culture than BALB/c when tested with cells from eleven other mouse strains with 10 MHC types (

).

Holan V., Lipoldova M., and Demant P. (1996) Identical genetic-control of MLC reactivity to different MHC incompatibilities, independent of production of and response to IL-2. Immunogenet. 44, 27-35.

Lush I.M. (1988) The genetics of tasting in mice. VI. Saccharin, acesulfame, dulcin and sucrose. Genet. Res. 53, 95-99.

Nishikawa R., Okumoto M., Iwai M., Iwai Y., Takamori Y., Imai S., and Hilgers J. (1991) Incomplete proviral genome of mouse mammary tumour virus is present on chromosome Y of NIH Swiss and some genetically related mouse strains. Lab. Anim. 25, 4-8.

van der Gugten A. A., Ropcke G., van Nie R., and Hilgers J. (1985) Mouse strain (STS/A) resistant to mammary tumor induction by hypophysial isografts. Cancer Res. 45, 3448-3453.

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