Inbred Strains of Mice: SSIN
SSINInbr (Utsp) 22+. Albino. Origin: 1970's, from outbred SENCAR (sensitive to carcinogens) selected for high skin tumour number following challenge for 10 generations with a topical application of dimethylbenz(a)anthracene followed by repetitive application of the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Inbred in 1986.
CharacteristicsHardy animals with low spontaneous tumour incidence; useful in chemical carcinogenesis studies because of extreme sensitivity to TPA (
Fischer et al 19870 1987). Low LD50 following injection of butylated hydroxytoluene (BHT) (4/4) (
Kehrer and DiGiovanni 1990)
Fischer S. M., O'Connell J. F., Conti C. J., Tacker K. C., Fries J. W., Patrick K. E., Adams L. A., and Slaga T. J. (1987) Characterization of an inbred strain of the SENCAR mice that is highly sensitive to phorbol esters. Carcinogenesis 8, 421-424. INBRED STRAINS OF MICERetroSearch is an open source project built by @garambo | Open a GitHub Issue
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