A RetroSearch Logo

Home - News ( United States | United Kingdom | Italy | Germany ) - Football scores

Search Query:

Showing content from http://www.informatics.jax.org/external/festing/mouse/docs/../docs/SELH.shtml below:

MGI - Inbred Strains: SELH

Inbred Strains of Mice: SELH

SELH

Inbr. F20+. Non-agouti, black, chinchilla (

aaBBcchcch

). Origin: A partially inbred stock of mixed background, including BALB/cGa, 129/- and CBA/- and homozygous for the lidgap-Gates (

lgGa

) was backcrossed to N3 in 1977 with outbred BLU:Ha(ICR) mice from Arbor Scientific Company, Ontario, Canada. A new recessive mutation spherocytosis-British Columbia

(sph2Bc

) appeared at the second intercross (N3xN3), and was selected for during brother x sister mating with the elimination of the lidgap-Gates mutation. Exencephaly was observed in 1981 at F5. Exencephaly producing parents were selected in subsequent generations, and all animals trace back to a single breeding pair at F6. The strain has been typed at 28 polymorphic loci (

Juriloff et al, 1989

). See also Gunn et al (

1992

).

Characteristics

High incidence of exencephaly at birth which has been attributed to two or three additive genetic loci which differ between SELH and the closely-related normal strain ICR/Bc. Defects may be related to abnormal cranial neural tube closure mechanism with a lack of the initiation of contact and fusion of the cranial neural tube at the prosencephalon/mesencephalon boundary (Closure 2). SELH mice undergo closure by extension of a more rostral site of fusion (

Gunn et al, 1995

) leading to 10-20% exencephaly, cleft cerebellum and 5-10% ataxia in young adults, which all appear to be causally related (

Juriloff et al, 1993, Gunn et al, 1995, Harris et al, 1994

). More sensitive to retinoic acid (

Tom et al, 1991

) and valproic acid-induced (

Hall et al, 1997

) exencephaly than SWV/Bc and ICR/Bc. The strain appears to have a high incidence of spontaneous mutations, including three at the albino locus (

Juriloff et al, 1994

).

Gunn T. M., Juriloff D. M., and Harris M. J. (1992) Further genetic studies of the cause of exencephaly in SELH mice. Teratology 45, 679-686.

Gunn T. M., Juriloff D. M., and Harris M. J. (1995) Genetically-determined absence of an initiation site of cranial neural-tube closure is causally related to exencephaly in SELH/Bc mouse embryos. Teratology 52, 101-108.

Hall J. L., Harris M. J., and Juriloff D. M. (1997) Effect of multifactorial genetic liability to exencephaly on the teratogenic effect of valproic acid in mice. Teratology 55, 306-313.

Harris M. J., Juriloff D. M., Gunn T. M., and Miller J. E. (1994) Development of the cerebellar defect in ataxic SELH/Bc mice. Teratology 50, 63-73.

Juriloff D. M., MacDonald K. B., and Harris M. J. (1989) Genetic analysis of the cause of exencephaly in the SELH/Bc mouse stock. Teratology 40, 395-405.

Juriloff D. M., Harris M. J., Harrod M. L., Gunn T. M., and Miller J. E. (1993) Ataxia and a cerebellar defect in the exencephaly-prone SELH/Bc mouse stock. Teratology 47, 333-340.

Juriloff D. M., Porter S. D., and Harris M. J. (1994) 3 spontaneous mutations at the albino locus in SELH/Bc mice. Genome 37, 190-197.

Tom C., Juriloff D. M., and Harris M. J. (1991) Studies of the effect of retinoic acid on anterior neural-tube closure in mice genetically liable to exencephaly. Teratology 43, 27-40.

INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

RetroSearch is an open source project built by @garambo | Open a GitHub Issue

Search and Browse the WWW like it's 1997 | Search results from DuckDuckGo

HTML: 3.2 | Encoding: UTF-8 | Version: 0.7.4