Inbred Strains of Mice: SAMP8
SAMP8Inbr ?+59. Origin: as SAMP1. Albino (
c).
Characteristics:
Shows accelerated aging (Takeda et al 1991). Deterioration in passive and active avoidance tasks progresses with advancing age and becomes significant at 4 and 8 months of age, respectively (Yagi et al 1988, Ohta et al 1989). Age-related massive occurrence of PAS-positive granular structures often observed in the hippocampus and spongiform degeneration of the reticular formation of the brain stem are unusual neuropathological findings (Akiyama et al 1986). Hippocampal glutamic acid content is higher than in SAMP1 (Nomura et al 1991). Median survivial time is 364 days in conventional conditions.
Akiyama H., Kameyama M., Akiguchi I., Sugiyama H., Kawamata T., Fukuyama H., Kimura H., Matsuchita M., and Takeda T. (1986) Periodic acid-Schiff (PAS)-positive, granular structures increase in the brain of senescence accelerated mouse (SAM). Acta Neuropathol. 72, 124-129. INBRED STRAINS OF MICERetroSearch is an open source project built by @garambo | Open a GitHub Issue
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