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MGI - Inbred Strains: RFM

Inbred Strains of Mice: RFM

Inbr 120 +. Albino

Origin: Furth, to Oak Ridge 1949. Strain has been found to be segregating for

and

and substrains also differ in other respects, so genetic contamination of some substrains must be suspected. Maint. by N.

Leukaemia low (5%), but highly susceptible to induction of both myeloid and lymphoid leukaemia by X-irradiation and chemical carcinogens (

). Spalding and Brooks (

) found that the strain was segregating for

and

Two substrains were developed with a mean life-span of 655 _ 8 days in the

substrain and 604 _ 10 days in the

substrain, implying that the

locus may affect survival. The substrains also differed in radiation resistance and spontaneous activity. The presence of genetic variation within this strain may imply that some substrains have become genetically contaminated by a non-strain mating. Develops a spontaneous myelogenous leukaemia that is transplantable into non-leukaemic mice of the same strain (

., 1976). Reticulum cell sarcomas 57% in males and 70% in females. Lung tumours 24% in males and 19% in females, and non-neoplastic moderate to severe glomerular lesions in more than 50% of animals (Zurcher

., 1976).

Spalding J. F. and Brooks M. R. (1971) The possible influence of a single gene locus on lifespan and its relationship to radiation resistance and activity. Proc. Soc. Exp. Biol. Med. 136, 1091-1093.

Walburg H. E. and Cosgrove G. E. (1971) Methycholanthrene-induced neoplasms in germfree RFM mice. Int. J. Cancer 8, 338-343.

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