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MGI - Inbred Strains: P

Inbred Strains of Mice: P

Inbr: 91. Origin: P. Kortweg 1934; DBA female x C57BL male, then N20 to C57BL, then b x s inbred.

Inbr: F153. Pink-eyed fawn. Genet:

Origin: Snell from a cross involving strain BDP. Carries the pink-eyed dilution gene,

, which is derived from Asian mice of the

type (see also strains SJL, 129/J and FS/Ei) (

)

Lymphatic leukaemia 22% in males and 29% in breeding, and 58% in virgin females. Primary lung tumours zero in males and 3% in females (

). Life-span short (3/22 = 384 days in males and 8/22 = 510 days in females) in conventional conditions (

). Low metabolic rate (15/18) (

). High serum ceruloplasmin levels in females (4/27) (

). High susceptibility to audiogenic and electroconvulsive seizures (1/6) (

., 1976). Large brain weight (15/18 in males, 14/18 in females) (

). Large brain/body weight ratio (1/20) and large spinal cord (2/25) (

., 1973). Resistant to X-irradiation (5/27) (

). Short survival in 90% oxygen (3/10) (

). Low lymphocyte phytohaemagglutinin response (37/43) (

., 1975). Intermediate breeding performance (15/24) (

., 1973).

High degree of genetic distinctiveness (8/27) (Taylor, 1972). Susceptible to colon carcinogenesis by 1,2-dimethylhydrazine (cf. 3/7) (Evans et al., 1977., 1977).

Deckard B. S., Lieff B., Schlesinger K., and DeFries J. C. (1976) Developmental patterns of seizure susceptibility in inbred strains of mice. Devel. Psychobiol. 9, 17.

Evans J. T., Shows T. B., Sproul E. E., Paolini N. S., Mittelman A., and Hauschka T. S. (1977) Genetics of colon carcinogenesis in mice treated with 1, 2-dimethylhydrazine. Cancer Res. 37, 134-136.

Hansen C. T., Judge F. J., and Whitney R. A. (1973) Catalog of NIH rodents. National Institutes of Health. DHEW publication (NIH) 74-606, Bethesda.

Heiniger H. J., Taylor B. A., Hards E. J., and Meier H. (1975) Heritability of the phytohaemagglutinin responsiveness of lymphocytes and its relationship to leukemogenesis. Cancer Res. 35, 825-831.

Hoag W. G. (1963) Spontaneous cancer in mice. Ann. NY Acad. Sci. 108, 805-831.

Lieberman J. and Kellog F. (1967) Hyaline-membrane formation and pulmonary plasminogen-activator activity in various strains of mice. Pediatrics 39, 75-81.

Meier H. and MacPike A. D. (1968) Levels and heritability of serum ceruloplasmin activity in inbred strains of mice. Proc. Soc. Exp. Biol. Med. 128, 1185-1190.

Roderick T. H., Wimer R. E., Wimer C. C., and Schwartzkroin P. A. (1973) Genetic and phenotypic variation in weight of brain and spinal cord between inbred strains of mice. Brain Res. 64, 345-353.

Roderick T. H. (1963) The response of twenty-seven inbred strains of mice to daily doses of whole-body X-irradiation. Radiation Res. 20, 631-639.

Storer J. B. (1966) Longevity and gross pathology at death in 22 inbred strains of mice. J. Gerontol. 21, 404-409.

Storer J. B. (1967) Relation of lifespan to brain weight, body weight and metabolic rate among inbred mouse strains. Exp. Gerontol. 2, 173-182.

Taylor B. A. (1972) Genetic relationship between inbred strains of mice. J. Hered. 63, 83-86.

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