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MGI - Inbred Strains: NZY

Inbred Strains of Mice: NZY

Inbr: F120 (Wehi). Cinnamon piebald (?). Genet:

Origin: see NZB; a piebald male appeared at F2 which was mated with a tan sister; at F4 a piebald brother-sister appeared; b x s mating with selection for piebald gene

led to fixation of the coat pattern at F7.

High incidence of mammary tumours and pituitary adenomas. Megacolon 10%, associated with the

gene (

). Highly susceptible to induction of connective tissue tumours by 4-nitroquinone

-oxide (1/5) (

). A subline has been developed: NZYf/Bu Inbr: 65 since fostering. Origin: NZY at F26 were fostered on NZC. A marked reduction in mammary cancer but pituitary tumour incidence unchanged.

Searle C. E. and Spencer A. T. (1966) Induction of tumours of connective tissue by repeated applications of 4-nitroquinoline N-oxide to mouse skin. Brit. J. Cancer 20, 877-885.

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