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MGI - Inbred Strains: NFS

Inbred Strains of Mice: NFS

Inbr (N) 57. Albino a,c. As for NFR, but selectively bred for sensitivity to the action of histamine after treatment with

Carries an incomplete proviral genome of endogenous mammary tumour virus (MMTV) on the Y chromosome (c.f. 4/10) (

). Susceptible to both acute and chronic cadmium toxicity (contrast BALB/c) (

). A mutant substrain NFS/NJic has a mutation

causing sublingual gland differentiation arrest (

). When these mice are thymectomised at 3 days of age they develop autoimmune sialadenitis, a model of human Sjogren's disease (

).

Maint. by A,N.

Hayashi Y., Haneji N., Hamano H., Yanagi K., Takahashi M., and Ishimaru N. (1996) Effector mechanism of experimental autoimmune sialadenitis in the mouse model for primary Sjogren's syndrome. Cell. Immunol. 171, 217-225.

Kojima a and Hata M. (1988) New mutant: sublingual gland differentiation arrest in the NFS/N subline. Mouse N.L. 80, 147.

Nishikawa R., Okumoto M., Iwai M., Iwai Y., Takamori Y., Imai S., and Hilgers J. (1991) Incomplete proviral genome of mouse mammary tumour virus is present on chromosome Y of NIH Swiss and some genetically related mouse strains. Lab. Anim. 25, 4-8.

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