Inbred Strains of Mice: MSM
MSMInbr. 20. White-bellied agouti
Aw,b,c.Origin: Wild mice trapped in Mishima City, Shizuoka Prefecture, Japan and inbred in 1979 by Moriwaki. Has not been crossed with laboratory mice. Previously called M.MOL-MSM. Resistant to the development of lymphoma, due to at least two loci in crosses involving strain SL/Kh (
Pataer et al, 1996). Fibroblast-like cells from the brains of these mice immortalise in tissue culture in a similar way to those of other strains (
Yuasa et al, 1996). C3HxMSM F1 hybrids treated with N-methyl-N-nitrosourea (MNU) develop squamous cell carcinomas of the forestomach with about 20% and 15% having mutations in H-
rasand p53, respectively (
Masui et al, 1997).
Masui T., Tezuka N., Nakanishi H., Inada K. I., Miyashita N., and Tatematsu M. (1997) Induction of invasive squamous cell carcinomas in the forestomach of (C3H x MSM)F1, MSM, and C3H mice by N-methyl-N-nitrosourea and mutational analysis of the H-ras and p53 genes. Cancer Lett. 111, 97-104. INBRED STRAINS OF MICERetroSearch is an open source project built by @garambo | Open a GitHub Issue
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