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MGI - Inbred Strains: MA

Inbred Strains of Mice: MA

Inbr (J): 132. Albino. Genet.

Origin: Marsh's strain 3. Started from a pair of mice from the Lathrop-Loeb colony (1903-1915). 32 generations of cousin mating by Marsh, to W.S.Murray who started b x s (

).

Primary lung tumours 37% in males, 42% in females. Lymphatic leukaemia 1% in males and breeding females, zero in virgin females. Mammary tumours zero (

). Low gross tumour incidence (22/22) (

). Polydipsia-polyuria (

), which may be associated with cysts pressing on posterior lobe of pituitary (

). Life-span intermediate in both sexes (7/22 = 459 days in males, 12/22 = 585 days in females) (

).

High metabolic rate (3/18) (Storer, 1967). High plasma cholinesterase activity in females (4/22) but low in males (18/22) (Angel et al., 1967., 1967). Low liver arylsulphatase activity (11/12) (Daniel, 1976). Only strain out of 29 tested that carries the mannosephosphate isomerase Mpi 1^a allele (Nichols et al., 1973., 1973).

Small spinal cord (23/25) (Roderick et al., 1973., 1973). Large kidney/body weight ratio (4/21) (Schlager, 1968). Large hippocampus (2/9) (Wimer et al., 1969., 1969). Fusion between left part of median lobe and left lateral lobe of liver is common (Bunker, 1959).

Resistant to X-irradiation (2/27 in J substrain, 7/27 in My substrain) (Roderick, 1963). Resistant to pulmonary hyaline-membrane formation (1/10) and long survival in 90% oxygen (3/10) (Lieberman and Kellog, 1967).

Highly susceptible to the mammary tumour virus, which is not normally carried by the strain (Murray and Little, 1967).

Bernstein S. E. (1966) Physiological characteristics, in Biology of the Laboratory Mouse, 2nd. ed. (Green E. L., ed), pp. 337-350. McGraw-Hill, New York.

Bunker L. E. (1959) Hepatic fusion, a new gene in linkage group I of the mouse. J. Hered. 50, 40-44.

Daniel W. L. (1976) Genetics of murine liver and kidney arylsulfatase B. Genetics 82, 477-491.

Hoag W. G. (1963) Spontaneous cancer in mice. Ann. NY Acad. Sci. 108, 805-831.

Lieberman J. and Kellog F. (1967) Hyaline-membrane formation and pulmonary plasminogen-activator activity in various strains of mice. Pediatrics 39, 75-81.

Murray W. S. and Little C. C. (1967) Genetic studies of carcinogenesis in mice. J. Natl. Cancer Inst. 38, 639-656.

Murray W. S. (1963) MA/My strain of the Marsh albino mouse. J. Natl. Cancer Inst. 30, 605-610.

Nichols E. A., Chapman V. M., and Ruddle F. H. (1973) Polymorphism and linkage for mannosephosphate isomerase in Mus musculus. Biochem. Genet. 8, 47-53.

Roderick T. H., Wimer R. E., Wimer C. C., and Schwartzkroin P. A. (1973) Genetic and phenotypic variation in weight of brain and spinal cord between inbred strains of mice. Brain Res. 64, 345-353.

Roderick T. H. (1963) The response of twenty-seven inbred strains of mice to daily doses of whole-body X-irradiation. Radiation Res. 20, 631-639.

Russell E. S. and Meier H. (1966) Constitutional diseases, in Biology of the Laboratory Mouse, 2nd. ed. (Green E. L., ed), pp. 571-587. McGraw-Hill, New York.

Schlager G. (1968) Kidney weight in mice: strain differences and genetic determination. J. Hered. 59, 171-174.

Storer J. B. (1966) Longevity and gross pathology at death in 22 inbred strains of mice. J. Gerontol. 21, 404-409.

Storer J. B. (1967) Relation of lifespan to brain weight, body weight and metabolic rate among inbred mouse strains. Exp. Gerontol. 2, 173-182.

Wimer R. E., Wimer C. C., and Roderick T. H. (1969) Genetic variability in forebrain structures between inbred strains of mice. Brain Res. 16, 257-264.

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