Inbred Strains of Mice: LT
LTInbr (Sv) 121. Colour: Light brown
a,Blt.Origin: MacDowell 1950 from a mutation at the brown locus in strain C58. Outcrossed to BALB/c. To Chase, to Re in 1957 at F28.
CharacteristicsOvarian teratomas occur spontaneously in about half of the females. Ultrastructurally the stem cells do not differ from those of testicular or embryo-derived teratomas (
Damjanov et al., 1975., 1975). Some tumours begin to develop at about 30 days and the incidence rises to 50% at 90 days. These resemble normal embryos until blastocyst stage and then become disorganised. A small percentage of ovulated eggs also develop parthenogenetically, but die at 5-7 days (
Stevens and Varnum, 1974). Oocytes arrest at metaphase of meiosis I rather than progressing to metaphase II like other strains. This is a necessary, but not sufficient condition for parthogenetic activation (Eppig et al, 1996). Metaphase I arrest is frequently followed by parthogenetic activation. Oocytes typically contain a single large centrosome with microtubules being shorter than usual (
Albertini and Eppig, 1995). Metaphase I arrest is associated with a sustained elevation of p34 (
Cdc2) kinase activity, sustained in part by restricted degradation of cyclin B (
Hampl and Eppig, 1995). Oocytes ovulated at metaphase I are not capable of undergoing normal fertilisation
in-vitro. Only 13% of such oocytes penetrated by sperm formed a diploid female pronucleus and a haploid male pronucleus by 4hr. after insemination (Maleszweski and Yanagimachi, 1995). Spontaneously digynic triploid embryos result from the fertilization of primary oocytes. These embryos develop to the forelimb-bud stage but invariably posess neural tube and cardiac abnormalities (
Henery and Kaufman, 1993). Treatment with cisplatin reduced the incidence of ovarian teratomas, and those that did develop were not transplantable (
Nishida et al, 1995). A locus on chromosome 6 designated
Ots1(ovarian teratoma susceptibility) is the single major locus that increases the frequency of teratomas in a semidominant manner (
Lee et al, 1997)
Albertini D. F. and Eppig J. J. (1995) Unusual cytoskeletal and chromatin configurations in mouse oocytes that are atypical in meiotic progression. Developmental Genetics 16, 13-19. INBRED STRAINS OF MICERetroSearch is an open source project built by @garambo | Open a GitHub Issue
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