Inbred Strains of Mice: Infection
InfectionMurine acquired immune deficiency (MAIDS) is an immunosuppressive disease of mice induced by infection with the LP-BM5 murine leukemia retrovirus. Strain BDP has a novel disease phenotype with recovery of immune function after a period of profound immune suppression. This is inherited as a dominant character in crosses with both susceptible and resistant strains (
Gilmore, 1997).
Gilmore G. L. (1997) Recovery from retrovirus-induced immune suppression in BDP/J mice: Dominance of the 'regressor' phenotype. Immunol. 90, 7-13. INBRED STRAINS OF MICEInbred Strains of Mice: Infection
Infection Resistant to polyoma virus-induced tumours due to a resistance gene Pyvr , which did not recombine with Mtv-7. Resistance can be overcome by irradiation, indicating an immunological basis (Lukacher et al, 1995). Resistant to Mycoplasma pulmonis infection (cf 4/16) (Cartner et al, 1996). Reproduction Intermediate breeding performance (12/25), colony output 0.98 young/female/week, litter size at weaning high at 6.5 (5/25) (Festing 1976a). Poor breeding performance (24/24) (Hansen et al., 1973., 1973). High ratio of females at birth (2/11) (Cook and Vlcek, 1961). Miscellaneous High degree of genetic distinctiveness (6/27) (Taylor, 1972). Recommended host for transplantable pituitary tumour BW8685 (Kaliss, 1972). High incidence of spontaneous `deviants' (possible mutations) (1/21) (Schlager and Dickie, 1967). Cartner S. C., Simecka J. W., Briles D. E., Cassell G. H., and Lindsey J. R. (1996) Resistance to Mycoplasmal lung-disease in mice is a complex genetic trait. Infect. Immun. 64, 5326-5331.Cook M. J. and Vlcek A. (1961) Sex ratio in mice. Nature 191, 89.
Taylor B. A. (1972) Genetic relationship between inbred strains of mice. J. Hered. 63, 83-86.
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