Inbred Strains of Mice: DW
DWInbr: F110 (J). Grey. Genet:
a, ln.Carries dwarf
(dw)mutation with forced heterozygosity.
dwmutation arose in a stock of silver mice obtained by Snell from an English fancier before 1929. Established by Jackson Laboratory in 1966 from stock supplied by Lane.
CharacteristicsThe dwarf mutation causes a reduction in acidophils and thyrotrophin-producing cells of the anterior pituitary. Mutant mice have a variety of anatomical, cytological and physiological defects due to deficiency of anterior pituitary hormone, including reduced growth and organ development and infertility. Pituitary homografts or injections of growth hormone and/or prolactin partially reverse some of these defects. Dwarf mice are almost tumour-free, whereas their normal litter mates have a high incidence of a range of tumours. However, dwarf mice also have a shorter life-span. Deficiencies of RNA metabolism in the liver have been noted (
Chen et al., 1972a, 1972a). Dwarf DW mice have a lower expression of group-specific antigen to endogenous C-type
RNA tumour virus than normal litter mates, which have 45-61% incidence of reticulum cell sarcoma (
Chen et al., 1972b, 1972b). A complete bibliography of the strain from 1967 to 1973 has been given by
Richardson (1973). The effects of prolactin on activity of 17-beta-hydroxysteroid dehydrogenase has been studied by Musto
et al. (
1972).
Chen H. W., Hamer D. H., Heiniger H. J., and Meier H. (1972a) Stimulation of hepatic RNA synthesis in dwarf mice by ovine prolactin. Biochim. Biophys. Acta 287, 90-97. INBRED STRAINS OF MICERetroSearch is an open source project built by @garambo | Open a GitHub Issue
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