Inbred Strains of Mice: DDK
DDKInbr: F105. Albino. Genet:
A,B,c,D,s. Developed by K. Kondo from outbred dd stock from Institute of Infectious Diseases, University of Tokyo, in 1944.
CharacteristicsDDK females mated to C57BL males are semi-sterile, but the reciprocal cross is fully fertile. The low `fertility' is caused by embryonic death at the morula-blastocyst or pre-egg cylinder stage 3-5 days after fertilisation. A deficit of trophoblast formation was observed. Transplantation experiments show that the defect is the property of the embryos, not the uterine environment. The DDK karyotype appears normal (
Wakasugi, 1973). Tendency to diabetes (
Nishimura, 1969). Nuclear transplantation experiments between hybrid eggs of BALB/c and DDK strains has shown that failure of F1 (DDK female x BALB/c male) embryos to develop is not due to the combination per se of maternal (DDK) and paternal (BALB/c) genomes but rather to an incompatibility between paternal (BALB/c) genomic contribution and DDK cytoplasm. This incompatibility does not occur between a female BALB/c pronucleus and the DDK cytoplasm, suggesting the involvement of a differential imprinting of parental genomes. (
Babinet et al 1990)
Babinet C., Richoux V., Guenet J. L., and Renard J. P. (1990) The DDK inbred strain as a model for the study of interactions between parental genomes and egg cytoplasm in mouse preimplantation development. Development - Supplement 1990, 81-87. INBRED STRAINS OF MICERetroSearch is an open source project built by @garambo | Open a GitHub Issue
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