Inbred Strains of Mice: CT
CTInbr (Lac) ?+8 . Agouti: +. Origin:
ct(curly-tail) mutation arose spontaneously in GFF inbred mice. Backcrossed to CBA an unknown number of times, then bxs of presumed
ct/cthomozygotes. Differs from CBA at many marker loci. Expression of the
ctgene ranges from spina-bifida causing pre-natal death to various degrees of kinky tail, to complete normality. The neural tube defects can be modified by environmental factors. Excess vitamin A increases the incidence, but low doses given at a particular stage of gestation can prevent the abnormalities (
Seller and Adinolfi 1981). The exencephaly and spina bifida are manifested independently of the maternal environment (
Seller et al 1981) Maint. by Lac.
Seller M. J. and Adinolfi M. (1981) The curley-tail mouse: an experimental model for human neural tube defects. Life Sci. 29, 1607-1615. INBRED STRAINS OF MICERetroSearch is an open source project built by @garambo | Open a GitHub Issue
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