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MGI - Inbred Strains: BRVR

Inbred Strains of Mice: BRVR

Inbr: F83+. Albino. Genet: c. Origin: Webster (1933a,b) developed two lines resistant and susceptible to infection by

(

sp.) by selection on the basis of a progeny test, followed by full-sib mating. Mortality under specified test conditions was 15% and 85%, respectively, and was about 39% in the unselected controls. Later tests (

) with louping ill and St Louis encephalitis viruses led to the development of three lines designated BSVS (bacteria-susceptible, virus-susceptible), BSVR (bacteria-susceptible, virus-resistant) and BRVS (bacteria-resistant, virus-susceptible). Later BRVR (bacteria-resistant, virus-resistant) mice were developed from a cross between BSVR and BRVS, with subsequent selection for resistance to the two agents, and full-sib mating. There may have been some confusion between the lines in the past, and authenticity should not always be assumed.

Hydronephrosis in 11% of females and 18% of males (1/13) (

), 34-42% in males and 30-34% in females (

., 1971). Resistant to

some encephalitic viruses and experimental allergic encephalomyelitis (

). Resistant to experimental allergic encephalomyelitis (cf. 6/14) (

). Resistant to induction of experimental autoimmune thyroiditis (cf. 2/5) (Vladutiu and Rose, 1971a). Carries gene for resistance to group B arbovirus infection (cf. strain PRI) (

., 1974). Differences between the responses of BRVR and BSVS to infections and various antigens are listed by Boehme(

).

Collins G. R., Goodheart C. R., and Henson D. (1971) Spontaneous heritable hydronephrosis in inbred mice. I. Description, incidence and distribution of lesions. Lab. Animal Sci. 22, 333-338.

Darnell M. B., Koprowski H., and Lagerspatz K. (1974) Genetically determined resistance to infection with group B arboviruses. I. Distribution of the resistance gene among various mouse populations and characteristics of gene expression in vivo. J. Infect. Dis. 129, 240-247.

Levine S. and Sowinski R. (1973) Experimental allergic encephelomyelitis in inbred and outbred mice. J. Immunol. 110, 139-143.

Staats J. (1976) Standardized nomenclature for inbred strains of mice: Sixth listing. Cancer Res. 36, 4333-4377.

Taylor D. M. and Fraser H. (1973) Hydronephrosis in inbred strains of mice with particular reference to the BRVR strain. Lab. Anim. 7, 229-236.

Webster L. T. (1937) Inheritance of resistance of mice to enteric bacterial and neurotropic virus infections. J. Exp. Med. 65, 261-286.

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