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Showing content from http://www.informatics.jax.org/external/festing/mouse/docs/../docs/BL.shtml below:

MGI - Inbred Strains: BL

Inbred Strains of Mice: BL

BL

Inbr: F108. Albino. Genet:

a, b, c

strain developed by Lynch from Bagg albino stock via Strong, and maintained at Rockefeller Institute since 1921.

Characteristics

Low mammary tumours, some lung tumours in older mice (

Staats, 1976

). Ovaries often appear pale and enlarged and have an infiltration of amyloid. Thought to be due to necrotising arteritis in which there is a thickening of the walls of the vessels to duodenum and ovaries due to a deposition of eosinophilic material within the intima and media (

Deringer, 1959b

). Aseptic necrosis of bone in 22% of females often resulting in fracture of femoral neck and other complications, so that the animals are severely crippled (

Sokoloff and Haberman, 1958

).

Deringer M. K. (1959b) Occurrence of tumors, particularly mammary tumors in agent-free strain C3HeB mice. J. Natl. Cancer Inst. 22, 995-1002.

Sokoloff L. and Haberman R. T. (1958) Idiopathic necrosis of bone in small animals. Arch. Pathol. 65, 323-330.

Staats J. (1976) Standardized nomenclature for inbred strains of mice: Sixth listing. Cancer Res. 36, 4333-4377.

INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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