Inbred Strains of Mice: BDP
BDPInbr: F94. Pink-eyed fawn. Genet:
a,
b, d, p, rd, se.Developed by W. H. Gates 1926 from a dilute brown female from Little and a pink-eyed female from Strong (
Staats, 1976). Inbred since 1926. Maint. by J.
BehaviourLow food drive (14/15) and high emotionality (2/15) (
Thompson, 1953). Nervous (
Staats, 1976).
Life-span and spontaneous disease
Short life-span in conventional conditions (4/22 = 421 days in males, 6/22 = 468 days in females) (Storer, 1966). Frequent mammary tumours, polycystic or granular kidneys (Staats, 1976).
Normal physiology and biochemistry
High plasma cholesterol at 12 and 24 weeks (3/8) (Weibust, 1973). Low porphyrin content of Harderian gland (2/16) (Margolis, 1971). High susceptibility to audiogenic and electroconvulsive seizures (2/6) (Deckard et al., 1976., 1976). High serum complement activity (c.f. 8/26) (Ong et al 1989)
AnatomyLarge kidney/body weight ratio (3/21) (
Schlager, 1968).
DrugsResistant to X-irradiation (8/27) (
Roderick, 1963).
ImmunologyErythrocytes have a high agglutinability (cf. 14/25) (
Rubinstein et al., 1974., 1974).
Deckard B. S., Lieff B., Schlesinger K., and DeFries J. C. (1976) Developmental patterns of seizure susceptibility in inbred strains of mice. Devel. Psychobiol. 9, 17.Weibust R. S. (1973) Inheritance of plasma cholesterol levels in mice. Genetics 73, 303-312.
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