Inbred Strains of Mice: VM
VM and VM-Sincs7Inbr. 81 (Dk). Albino. Genet.
a,b,c,d.,
H2b, Mlsa.Origin: Inbred as `5M' from Moredun Inst. stock (
Dickinson and Mackay, 1964), and name later changed to conform with nomenclature rules (
Dickinson et al., 1968., 1968). Congenic mouse strains VM/Dk and VM-Sincs7/Dk differ at the Sinc gene, which controls the incubation period of scrapie in mice; VM/Dk mice are Sincp7p7 and VM-Sincs7/Dk mice are Sincs7s7. Restriction fragment length polymorphism and DNA sequencing analysis demonstrated that the PrP genes also differ in these strains (
Hunter et al 1992)
CharacteristicsLong incubation of ME 7 scrapie agent and short incubation of 22A compared with most other strains (
Dickinson and Meikle, 1971). Spontaneous astrocytomas occur at 1.5% incidence. Tumours are largely confined to white matter areas, and have not been seen in sixteen other strains. Also has high incidence (1/6) of developmental defects, including cleft palate, subcutaneous blebs, facial and tail defects and cranial meningocoele (
Fraser, 1971), including spina bifida (Dickinson, 1977).
Dickinson A. G. and Mackay J. M. K. (1964) Genetical control of the incubation period in mice of the neurological disease, scrapie. Heredity 19, 279-288.Fraser H. (1971) Astrocytomas in an inbred mouse strain. J. Pathol. 103, 266-270.
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