Inbred Strains of Mice: SB
SBInbr (Le) 101. Pale grey.
sa,bg,Aw.Origin: mutations to
saand
bg,possibly rediation-induced, occurred independently in stocks used for mutation rate studies at Oak Ridge. Rl to Le 1961, then sib-mated.
CharacteristicsDevelops progressive infectious pneumonitis associated with the beige gene. Also has a high incidence of lymphadenopathy, including reticulum cell neoplasms and atypical lympho-proliferative lesions. Beige mice have giant lysosomal granules in the leukocytes and pigment dilution closely analogous to the Chediak-Higashi syndrome in man and similar disorders in mink and cattle. These mice appear to be a suitable model for the study of the increased susceptibility to infection seen with this syndrome (
Lane and Murphy, 1972).
Lane P. W. and Murphy E. D. (1972) Susceptibility to spontaneous pneumonitis in an inbred strain of beige and satin mice. Genetics 72, 451-460. INBRED STRAINS OF MICERetroSearch is an open source project built by @garambo | Open a GitHub Issue
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