Inbred Strains of Mice: RLC
RLCInbr. F20+?. Albino. Genet.
rlc/rlc.Origin: A spontaneous autosomal recessive mutation with rupture of the lens capsule and dislocation of the lens nucleus, designated
rlcoccurred in the CXSN/A strain. This was crossed with BALB/c followed by more than 20 generations of sib mating.
CharacteristicsOpacity of the lens of both eyes develops spontaneously at 35-60 days of age. Histologically there is irregular swelling, condensation, degeneration and fragmentation of lens fibers in the deep cortex, leading to rupture of the lens capsule at the posterior pole at 45-100 days of age. Following rupture, the lens nucleus dislocates behind the lens or occasionally in the anterior chamber (
Iida et al, 1997). The gene maps to the middle section of chromosome 14 near D14Mit39 at about position 30.0 (
Matsushima et al, 1996).
Iida F., Matsushima Y., Hiai H., Uga S., and Honda Y. (1997) Rupture of lens cateract: a novel hereditary recessive cateract model in the mouse. Exp. Eye Res. 64, 107-113. INBRED STRAINS OF MICERetroSearch is an open source project built by @garambo | Open a GitHub Issue
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