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MGI - Inbred Strains: PBA

Inbred Strains of Mice: PBA

PBA

Inbr: F20 +. Albino. Genet: c. Origin: P. C. Bailey from a pair of pet shop mice purchased in Birmingham, Alabama, in 1958.

Characteristics

Litter size 6.1; 6 week weight 21 g (both sexes); mean life-span 317 days in males, 268 days in females. Spontaneous lymphomas 100%, mammary tumours 74%, pulmonary adenomas 77% in animals over 1 year (

Bailey et al., 1970

., 1970). Development of spontaneous adenomas associated with increased serum concentration of IgG

1

and IgG

2

immunoglobulins (

Schrohenloher and Bailey, 1972

).

Bailey P. C., Leach W. B., and Hartley M. W. (1970) Characteristics of a new inbred strain of mice (PBA) with a high tumor incidence: preliminary report. J. Natl. Cancer Inst. 45, 59-73.

Schrohenloher R. E. and Bailey P. C. (1972) Atypical immunoglobulins associated with spontaneous lymphomas in an inbred strain of mice. J. Natl. Cancer Inst. 49, 1027-1037.

INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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