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Mon Sep 19 15:25:16 EDT 2005 · http://mail.python.org/pipermail/python-list/2005-September/333288.html

>>> rs='AUGCUAGACGUGGAGUAG'
>>> rs[12:15]='GAG'
Traceback (most recent call last):
  File "<pyshell#119>", line 1, in ?
    rs[12:15]='GAG'
TypeError: object doesn't support slice assignment

You can't assign to a section of a sliced string in
Python 2.3 and there doesn't seem to be mention of this
as a Python 2.4 feature (don't have time to actually try
2.4 yet).

Q1. Does extended slicing make use of the Sequence protocol?
Q2. Don't strings also support the Sequence protcol?
Q3. Why then can't you make extended slicing assignment work
    when dealing with strings?

This sort of operation (slicing/splicing of sequences represented
as strings) would seem to be a very fundamental oepration when doing
rna/dna/protein sequencing algorithms, and it would greatly enhance
Python's appeal to those doing bioinformatics work if the slicing
and extended slicing operators worked to their logical limit.

Doing a cursory search doesn't seem to reveal any current PEPs
dealing with extending the functionality of slicing/extended
slicing operators.

Syntax and feature-wise, is there a reason why Python can't kick
Perl's butt as the dominant language for bioinformatics and
eventually become the lingua franca of this fast-growing and
funding-rich field?

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Showing content from http://mail.python.org/pipermail/python-list/2005-September/333288.html below:

slicing functionality for strings / Python suitability for bioinformatics