Performs comparative bioavailability calculations for Average Bioequivalence with Expanding Limits (ABEL). Implemented are 'Method A' / 'Method B' and the detection of outliers. If the design allows, assessment of the empiric Type I Error and iteratively adjusting alpha to control the consumer risk. Average Bioequivalence - optionally with a tighter (narrow therapeutic index drugs) or wider acceptance range (South Africa: Cmax) - is implemented as well.
Version: 1.1.3 Depends: R (≥ 3.5.0) Imports: readxl (≥ 1.0.0), PowerTOST (≥ 1.5.3), lmerTest, nlme, pbkrtest, graphics, grDevices Suggests: knitr, rmarkdown, testthat, devtools Published: 2022-05-02 DOI: 10.32614/CRAN.package.replicateBE Author: Helmut Schütz [aut, cre], Michael Tomashevskiy [ctb], Detlew Labes [ctb] Maintainer: Helmut Schütz <helmut.schuetz at bebac.at> BugReports: https://github.com/Helmut01/replicateBE/issues License: GPL (≥ 3) URL: https://github.com/Helmut01/replicateBE NeedsCompilation: no Materials: README NEWS In views: ClinicalTrials CRAN checks: replicateBE results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=replicateBE to link to this page.
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