Implements statistical methods for estimating disease penetrance in family-based studies. Penetrance refers to the probability of disease§ manifestation in individuals carrying specific genetic variants. The package provides tools for age-specific penetrance estimation, handling missing data, and accounting for ascertainment bias in family studies. Cite as: Kubista, N., Braun, D. & Parmigiani, G. (2024) <doi:10.48550/arXiv.2411.18816>.
Version: 0.1.1 Depends: R (≥ 3.5.0) Imports: clipp, stats, parallel, MASS, kinship2 (≥ 1.8.5), graphics, grDevices Suggests: knitr, rmarkdown, scales, ggplot2, roxygen2, testthat (≥ 3.0.0) Published: 2025-04-02 DOI: 10.32614/CRAN.package.penetrance Author: Nicolas Kubista [aut, cre], BayesMendel Lab [aut] Maintainer: Nicolas Kubista <bmendel at jimmy.harvard.edu> License: GPL-3 URL: https://github.com/nicokubi/penetrance, https://nicokubi.github.io/penetrance/ NeedsCompilation: no SystemRequirements: C++11 Materials: README CRAN checks: penetrance results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=penetrance to link to this page.
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