A joint mixture model has been developed by Majumdar et al. (2025) <doi:10.48550/arXiv.2412.17511> that integrates information from gene expression data and methylation data at the modelling stage to capture their inherent dependency structure, enabling simultaneous identification of differentially methylated cytosine-guanine dinucleotide (CpG) sites and differentially expressed genes. The model leverages a joint likelihood function that accounts for the nested structure in the data, with parameter estimation performed using an expectation-maximisation algorithm.
Version: 1.0.0 Depends: R (≥ 3.5.0) Imports: foreach, doParallel, parallel, mclust, stats, utils, edgeR, magrittr, ggplot2, scales, tidyr, dplyr, reshape2, gridExtra, grid, tidyselect, cowplot Suggests: rmarkdown, knitr Published: 2025-01-13 DOI: 10.32614/CRAN.package.idiffomix Author: Koyel Majumdar [cre, aut], Isobel Claire Gorley [aut], Thomas Brendan Murphy [aut], Florence Jaffrezic [aut], Andrea Rau [aut] Maintainer: Koyel Majumdar <koyelmajumdar.phdresearch at gmail.com> License: GPL-3 NeedsCompilation: yes CRAN checks: idiffomix results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=idiffomix to link to this page.
RetroSearch is an open source project built by @garambo | Open a GitHub Issue
Search and Browse the WWW like it's 1997 | Search results from DuckDuckGo
HTML:
3.2
| Encoding:
UTF-8
| Version:
0.7.4