A genetic analysis tool and variance component model for identifying marginal epistasis between pathways and the rest of the genome. 'MAPITR' uses as input a matrix of genotypes, a vector of phenotypes, and a list of pathways. 'MAPITR' then iteratively tests each pathway for epistasis between any variants within the pathway versus any variants remaining in the rest of the genome. 'MAPITR' returns results in the form of p-values for every pathway indicating whether the null model of there being no epistatic interactions between a pathway and the rest of the genome can be rejected.
Version: 1.1.2 Depends: R (≥ 3.3.0) Imports: stats, doParallel, Rcpp (≥ 1.0.5), CompQuadForm LinkingTo: Rcpp, RcppArmadillo Suggests: testthat, knitr, rmarkdown Published: 2020-09-28 DOI: 10.32614/CRAN.package.MAPITR Author: Michael Turchin [aut, cre], Gregory Darnell [aut, ctb], Lorin Crawford [aut, ctb], Sohini Ramachandran [aut], Peter Carbonetto [ctb] Maintainer: Michael Turchin <michael_turchin at brown.edu> BugReports: https://github.com/mturchin20/MAPITR/issues License: MIT + file LICENSE URL: https://github.com/mturchin20/MAPITR NeedsCompilation: yes Materials: README CRAN checks: MAPITR results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=MAPITR to link to this page.
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