We developed a package 'Keyboard' for designing single-agent, drug-combination, or phase I/II dose-finding clinical trials. The 'Keyboard' designs are novel early phase trial designs that can be implemented simply and transparently, similar to the 3+3 design, but yield excellent performance, comparable to those of more-complicated, model-based designs (Yan F, Mandrekar SJ, Yuan Y (2017) <doi:10.1158/1078-0432.CCR-17-0220>, Li DH, Whitmore JB, Guo W, Ji Y. (2017) <doi:10.1158/1078-0432.CCR-16-1125>, Liu S, Johnson VE (2016) <doi:10.1093/biostatistics/kxv040>, Zhou Y, Lee JJ, Yuan Y (2019) <doi:10.1002/sim.8475>, Pan H, Lin R, Yuan Y (2020) <doi:10.1016/j.cct.2020.105972>). The 'Keyboard' package provides tools for designing, conducting, and analyzing single-agent, drug-combination, and phase I/II dose-finding clinical trials. For more details about how to use this packge, please refer to Li C, Sun H, Cheng C, Tang L, and Pan H. (2022) "A software tool for both the maximum tolerated dose and the optimal biological dose finding trials in early phase designs". Manuscript submitted for publication.
Version: 0.1.3 Depends: R (≥ 3.4.0), Rcpp (≥ 0.12.0), methods Imports: Iso, ggplot2 Published: 2022-08-11 DOI: 10.32614/CRAN.package.Keyboard Author: Xiaomeng Yuan, Chen Li, Hongying Sun, Li Tang and Haitao Pan Maintainer: Xiaomeng Yuan <xiaomeng.yuan at stjude.org> License: GPL-2 NeedsCompilation: no CRAN checks: Keyboard results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=Keyboard to link to this page.
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