Performs multi-omic differential network analysis by revealing differential interactions between molecular entities (genes, proteins, transcription factors, or other biomolecules) across the omic datasets provided. For each omic dataset, a differential network is constructed where links represent statistically significant differential interactions between entities. These networks are then integrated into a comprehensive visualization using distinct colors to distinguish interactions from different omic layers. This unified display allows interactive exploration of cross-omic patterns, such as differential interactions present at both transcript and protein levels. For each link, users can access differential statistical significance metrics (p values or adjusted p values, calculated via robust or traditional linear regression with interaction term) and differential regression plots. The methods implemented in this package are described in Sciacca et al. (2023) <doi:10.1093/bioinformatics/btad192>.
Version: 1.0.0 Depends: R (≥ 4.4.0) Imports: DT, grDevices, graphics, knitr, MASS, magrittr, methods, parallel, pbapply, pbmcapply, rmarkdown, sfsmisc, shiny, shinydashboard, stats, utils, visNetwork Suggests: qvalue, testthat (≥ 3.0.0) Published: 2025-06-05 DOI: 10.32614/CRAN.package.multiDEGGs Author: Elisabetta Sciacca [aut, cre, cph], Myles Lewis [ctb] Maintainer: Elisabetta Sciacca <e.sciacca at qmul.ac.uk> BugReports: https://github.com/elisabettasciacca/multiDEGGs/issues License: GPL-3 URL: https://github.com/elisabettasciacca/multiDEGGs/ NeedsCompilation: no Language: en-gb Citation: multiDEGGs citation info Materials: README NEWS CRAN checks: multiDEGGs results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=multiDEGGs to link to this page.
RetroSearch is an open source project built by @garambo | Open a GitHub Issue
Search and Browse the WWW like it's 1997 | Search results from DuckDuckGo
HTML:
3.2
| Encoding:
UTF-8
| Version:
0.7.4