Estimates statistically significant marker combination values within which one immunologically distinctive group (i.e., disease case) is more associated than another group (i.e., healthy control), successively, using various combinations (i.e., "gates") of markers to examine features of cells that may be different between groups. For a two-group comparison, the 'gateR' package uses the spatial relative risk function estimated using the 'sparr' package. Details about the 'sparr' package methods can be found in the tutorial: Davies et al. (2018) <doi:10.1002/sim.7577>. Details about kernel density estimation can be found in J. F. Bithell (1990) <doi:10.1002/sim.4780090616>. More information about relative risk functions using kernel density estimation can be found in J. F. Bithell (1991) <doi:10.1002/sim.4780101112>.
Version: 0.1.15 Depends: R (≥ 3.5.0) Imports: fields, graphics, grDevices, lifecycle, rlang, sparr, SpatialPack, spatstat.geom, stats, terra, tibble Suggests: dplyr, R.rsp, spelling, testthat, usethis, utils Published: 2024-01-23 DOI: 10.32614/CRAN.package.gateR Author: Ian D. Buller [aut, cre, cph], Elena Hsieh [ctb], Debashis Ghosh [ctb], Lance A. Waller [ctb], NCI [cph] Maintainer: Ian D. Buller <ian.buller at alumni.emory.edu> BugReports: https://github.com/lance-waller-lab/gateR/issues License: Apache License (≥ 2.0) URL: https://github.com/lance-waller-lab/gateR NeedsCompilation: no Language: en-US Citation: gateR citation info Materials: README NEWS CRAN checks: gateR results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=gateR to link to this page.
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