Implementation of gene-level rare variant association tests targeting allelic series: genes where increasingly deleterious mutations have increasingly large phenotypic effects. The COding-variant Allelic Series Test (COAST) operates on the benign missense variants (BMVs), deleterious missense variants (DMVs), and protein truncating variants (PTVs) within a gene. COAST uses a set of adjustable weights that tailor the test towards rejecting the null hypothesis for genes where the average magnitude of effect increases monotonically from BMVs to DMVs to PTVs. See McCaw ZR, OâDushlaine C, Somineni H, Bereket M, Klein C, Karaletsos T, Casale FP, Koller D, Soare TW. (2023) "An allelic series rare variant association test for candidate gene discovery" <doi:10.1016/j.ajhg.2023.07.001>.
Version: 0.1.1.5 Imports: CompQuadForm, glue, methods, Rcpp, RNOmni, SKAT LinkingTo: Rcpp, RcppArmadillo Suggests: knitr, rmarkdown, testthat (≥ 3.0.0), withr Published: 2025-04-02 DOI: 10.32614/CRAN.package.AllelicSeries Author: Zachary McCaw [aut, cre], Christoph Klein [ctb], Thomas Soare [ctb], Jianhui Gao [ctb], insitro [cph] Maintainer: Zachary McCaw <zmccaw at alumni.harvard.edu> License: BSD_3_clause + file LICENSE URL: https://github.com/insitro/AllelicSeries NeedsCompilation: yes Materials: NEWS CRAN checks: AllelicSeries results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=AllelicSeries to link to this page.
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