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CRAN: Package nlmixr2

nlmixr2: Nonlinear Mixed Effects Models in Population PK/PD

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Version: 4.0.0 Imports: cli (≥ 1.0.0), crayon (≥ 1.3.4), dplyr (≥ 0.7.4), purrr (≥ 0.2.4), rstudioapi (≥ 0.7), nlmixr2est (≥ 2.2.2), nlmixr2extra (≥ 2.0.10), rxode2 (≥ 2.1.3), lotri (≥ 0.4.3), nlmixr2plot (≥ 2.0.8), tibble, magrittr, crayon, cli Suggests: rmarkdown, knitr, devtools, ggplot2, testthat, n1qn1, withr Published: 2025-07-17 DOI: 10.32614/CRAN.package.nlmixr2 Author: Matthew Fidler [aut, cre], Anne Keunecke [ctb], Rik Schoemaker [ctb], Justin Wilkins [ctb], Wenping Wang [ctb], Mirjam Trame [ctb], John Harrold [ctb], Bill Denney [ctb], Theodoros Papathanasiou [ctb], Richard Hooijmaijers [ctb], Michael Wayne Kearney [ctb] Maintainer: Matthew Fidler <matthew.fidler at gmail.com> BugReports: https://github.com/nlmixr2/nlmixr2/issues/ License: GPL (≥ 3) URL: https://nlmixr2.org/, https://github.com/nlmixr2/nlmixr2/ NeedsCompilation: no Citation: nlmixr2 citation info Materials: README, NEWS In views: DifferentialEquations, HighPerformanceComputing, MixedModels, Pharmacokinetics CRAN checks: nlmixr2 results Documentation: Downloads: Reverse dependencies: Linking:

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