Provides comprehensive tools for blinded sample size re-estimation (BSSR) in two-arm clinical trials with binary endpoints. Unlike traditional fixed-sample designs, BSSR allows adaptive sample size adjustments during trials while maintaining statistical integrity and study blinding. Implements five exact statistical tests: Pearson chi-squared, Fisher exact, Fisher mid-p, Z-pooled exact unconditional, and Boschloo exact unconditional tests. Supports restricted, unrestricted, and weighted BSSR approaches with exact Type I error control. Statistical methods based on Mehrotra et al. (2003) <doi:10.1111/1541-0420.00051> and Kieser (2020) <doi:10.1007/978-3-030-49528-2_21>.
Version: 1.0.2 Depends: R (≥ 3.5.0) Imports: fpCompare, stats Suggests: testthat (≥ 3.0.0), knitr, rmarkdown, dplyr, ggplot2, tibble, tidyr, Exact, exact2x2, microbenchmark Published: 2025-06-18 DOI: 10.32614/CRAN.package.bbssr Author: Gosuke Homma [aut, cre] Maintainer: Gosuke Homma <my.name.is.gosuke at gmail.com> BugReports: https://github.com/gosukehommaEX/bbssr/issues License: MIT + file LICENSE URL: https://github.com/gosukehommaEX/bbssr NeedsCompilation: no Materials: NEWS CRAN checks: bbssr results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=bbssr to link to this page.
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