Fit and simulate any kind of physiologically-based kinetic ('PBK') models whatever the number of compartments. Moreover, it allows to account for any link between pairs of compartments, as well as any link of each of the compartments with the external medium. Such generic PBK models have today applications in pharmacology (PBPK models) to describe drug effects, in toxicology and ecotoxicology (PBTK models) to describe chemical substance effects. In case of exposure to a parent compound (drug or chemical) the 'rPBK' package allows to consider metabolites, whatever their number and their phase (I, II, ...). Last but not least, package 'rPBK' can also be used for dynamic flux balance analysis (dFBA) to deal with metabolic networks. See also Charles et al. (2022) <doi:10.1101/2022.04.29.490045>.
Version: 0.2.5 Depends: R (≥ 3.4.0) Imports: ggplot2, methods, Rcpp (≥ 0.12.0), rstan (≥ 2.26.0), rstantools LinkingTo: BH (≥ 1.66.0), Rcpp (≥ 0.12.0), RcppEigen (≥ 0.3.3.3.0), RcppParallel (≥ 5.0.1), rstan (≥ 2.26.0), StanHeaders (≥ 2.26.0) Suggests: knitr, loo, rmarkdown, testthat Published: 2025-06-12 DOI: 10.32614/CRAN.package.rPBK Author: Virgile Baudrot [aut, cre], Sandrine Charles [aut], Christelle Lopes [aut], Ophélia Gestin [ctb], Dominique Lamonica [ctb], Aurélie Siberchicot [ctb] Maintainer: Virgile Baudrot <virgile.baudrot at qonfluens.com> BugReports: https://gitlab.in2p3.fr/mosaic-software/rPBK/-/issues License: MIT + file LICENSE URL: https://gitlab.in2p3.fr/mosaic-software/rPBK/ NeedsCompilation: yes SystemRequirements: GNU make Materials: README CRAN checks: rPBK results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=rPBK to link to this page.
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