Implementation of LT-FH++, an extension of the liability threshold family history (LT-FH) model. LT-FH++ uses a Gibbs sampler for sampling from the truncated multivariate normal distribution and allows for flexible family structures. LT-FH++ was first described in Pedersen, Emil M., et al. (2022) <doi:10.1016/j.ajhg.2022.01.009> as an extension to LT-FH with more flexible family structures, and again as the age-dependent liability threshold (ADuLT) model Pedersen, Emil M., et al. (2023) <https://www.nature.com/articles/s41467-023-41210-z> as an alternative to traditional time-to-event genome-wide association studies, where family history was not considered.
Version: 2.1.4 Imports: batchmeans, dplyr, future.apply, future, purrr, Rcpp, rlang, stats, stringr, tibble, tmvtnorm, tidyselect, igraph, xgboost, tidyr LinkingTo: Rcpp Suggests: MASS, knitr, rmarkdown, kinship2, testthat Published: 2025-05-26 DOI: 10.32614/CRAN.package.LTFHPlus Author: Emil Michael Pedersen [aut, cre], Florian Privé [aut, ths], Bjarni Jóhann Vilhjálmsson [ths], Esben Agerbo [ths], Jette Steinbach [aut], Lucas Rasmussen [ctb] Maintainer: Emil Michael Pedersen <emp at ph.au.dk> BugReports: https://github.com/EmilMiP/LTFHPlus/issues License: GPL-3 URL: https://github.com/EmilMiP/LTFHPlus NeedsCompilation: yes Language: en-GB Materials: README NEWS CRAN checks: LTFHPlus results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=LTFHPlus to link to this page.
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