Bayesian logistic regression model with optional EXchangeability-NonEXchangeability parameter modelling for flexible borrowing from historical or concurrent data-sources. The safety model can guide dose-escalation decisions for adaptive oncology Phase I dose-escalation trials which involve an arbitrary number of drugs. Please refer to Neuenschwander et al. (2008) <doi:10.1002/sim.3230> and Neuenschwander et al. (2016) <doi:10.1080/19466315.2016.1174149> for details on the methodology.
Version: 0.9-3 Depends: R (≥ 3.5.0), RBesT (≥ 1.8-0) Imports: methods, Rcpp (≥ 0.12.0), RcppParallel (≥ 5.0.1), rstan (≥ 2.32.0), rstantools (≥ 2.4.0), posterior (≥ 1.5.0), assertthat (≥ 0.2.1), checkmate, Formula, bayesplot (≥ 1.4.0), ggplot2 (≥ 3.0.0), dplyr (≥ 1.1.0), tibble, tidyr (≥ 1.0.0), abind, scales, rlang (≥ 0.3.0), tidyselect, utils, stats, matrixStats, brms, lifecycle, grDevices LinkingTo: BH (≥ 1.75.0), Rcpp (≥ 0.12.0), RcppEigen (≥ 0.3.3.3.0), RcppParallel (≥ 5.0.1), rstan (≥ 2.32.0), StanHeaders (≥ 2.32.0) Suggests: rmarkdown, knitr, testthat (≥ 2.0.0), withr, mvtnorm, vdiffr, cmdstanr (≥ 0.4.0), ragg Published: 2025-04-25 DOI: 10.32614/CRAN.package.OncoBayes2 Author: Novartis Pharma AG [cph], Sebastian Weber [aut, cre], Lukas A. Widmer [aut], Andrew Bean [aut], Trustees of Columbia University [cph] (R/stanmodels.R, configure, configure.win) Maintainer: Sebastian Weber <sebastian.weber at novartis.com> License: GPL (≥ 3) NeedsCompilation: yes SystemRequirements: GNU make, pandoc (>= 1.12.3), pngquant, C++17 Additional_repositories: https://mc-stan.org/r-packages/ Materials: NEWS CRAN checks: OncoBayes2 results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=OncoBayes2 to link to this page.
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