A multiple testing procedure aims to find the rare-variant association regions. When variants are rare, the single variant association test approach suffers from low power. To improve testing power, the procedure dynamically and hierarchically aggregates smaller genome regions to larger ones and performs multiple testing for disease associations with a controlled node-level false discovery rate. This method are members of the family of ancillary information assisted recursive testing introduced in Pura, Li, Chan and Xie (2021) <doi:10.48550/arXiv.1906.07757> and Li, Sung and Xie (2021) <doi:10.48550/arXiv.2103.11085>.
Version: 0.1 Depends: R (≥ 3.5.0) Imports: data.table, tidyverse, Matrix, reshape2, stats, methods, tibble, dplyr Suggests: knitr, rmarkdown Published: 2022-10-14 DOI: 10.32614/CRAN.package.DYNATE Author: Xuechan Li [aut, cre], Jichun Xie [ctb] Maintainer: Xuechan Li <xuechanli0530 at gmail.com> License: GPL-3 NeedsCompilation: no Materials: README CRAN checks: DYNATE results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=DYNATE to link to this page.
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