A systematic biology tool was developed to repurpose drugs via a subpathway crosstalk network. The operation modes include 1) calculating centrality scores of SPs in the context of gene expression data to reflect the influence of SP crosstalk, 2) evaluating drug-disease reverse association based on disease- and drug-induced SPs weighted by the SP crosstalk, 3) identifying cancer candidate drugs through perturbation analysis. There are also several functions used to visualize the results.
Version: 0.1.5 Depends: R (≥ 3.6) Imports: GSVA, clusterProfiler, graphics, igraph, pheatmap, stats Suggests: rmarkdown, knitr, DT Published: 2025-01-09 DOI: 10.32614/CRAN.package.DRviaSPCN Author: Junwei Han [aut, cre, cph], Jiashuo Wu [aut] Maintainer: Junwei Han <hanjunwei1981 at 163.com> License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] NeedsCompilation: no CRAN checks: DRviaSPCN results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=DRviaSPCN to link to this page.
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