Based on the illness-death model a large number of clinical trials with oncology endpoints progression-free survival (PFS) and overall survival (OS) can be simulated, see Meller, Beyersmann and Rufibach (2019) <doi:10.1002/sim.8295>. The simulation set-up allows for random and event-driven censoring, an arbitrary number of treatment arms, staggered study entry and drop-out. Exponentially, Weibull and piecewise exponentially distributed survival times can be generated. The correlation between PFS and OS can be calculated.
Version: 0.1.0 Depends: R (≥ 3.6) Imports: checkmate, furrr, future, mstate, parallelly, stats, survival Suggests: coxphw, knitr, mvna, prodlim, rmarkdown, rpact, testthat (≥ 3.0.0) Published: 2023-12-11 DOI: 10.32614/CRAN.package.simIDM Author: Alexandra Erdmann [aut, cre], Kaspar Rufibach [aut], Holger Löwe [aut], Daniel Sabanés Bové [aut], F. Hoffmann-La Roche AG [cph, fnd], University of Ulm [cph, fnd] Maintainer: Alexandra Erdmann <alexandra.erdmann at uni-ulm.de> BugReports: https://github.com/insightsengineering/simIDM/issues License: Apache License 2.0 URL: https://github.com/insightsengineering/simIDM/ NeedsCompilation: no Language: en-US Materials: NEWS CRAN checks: simIDM results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=simIDM to link to this page.
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