Applying the global sensitivity analysis workflow to investigate the parameter uncertainty and sensitivity in physiologically based kinetic (PK) models, especially the physiologically based pharmacokinetic/toxicokinetic model with multivariate outputs. The package also provides some functions to check the convergence and sensitivity of model parameters. The workflow was first mentioned in Hsieh et al., (2018) <doi:10.3389/fphar.2018.00588>, then further refined (Hsieh et al., 2020 <doi:10.1016/j.softx.2020.100609>).
Version: 1.2.3 Depends: R (≥ 4.1) Imports: ggplot2, data.table, deSolve, foreach, parallel, doParallel Suggests: covr, knitr, httk, rmarkdown, testthat Published: 2022-09-21 DOI: 10.32614/CRAN.package.pksensi Author: Nan-Hung Hsieh [aut, cre], Brad Reisfeld [ctb], Weihsueh A. Chiu [ctb] Maintainer: Nan-Hung Hsieh <d99622005 at ntu.edu.tw> BugReports: https://github.com/nanhung/pksensi/issues License: GPL-3 | file LICENSE URL: https://github.com/nanhung/pksensi, https://nanhung.github.io/pksensi/ NeedsCompilation: no Language: en-US Citation: pksensi citation info Materials: NEWS CRAN checks: pksensi results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=pksensi to link to this page.
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