Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>). This package is for support functions like preconditioned fits <doi:10.1208/s12248-016-9866-5>, boostrap and stepwise covariate selection.
Version: 3.0.2 Depends: R (≥ 4.0) Imports: checkmate, cli (≥ 3.4.0), crayon, data.table, digest, dplyr, ggplot2, ggtext, knitr, lotri, methods, nlme, nlmixr2est (≥ 2.1.1), Rcpp, rxode2 (≥ 2.0.10), stats, symengine, utils LinkingTo: Rcpp, RcppArmadillo Suggests: brms, nlmixr2data, testthat (≥ 3.0.0), withr, devtools Published: 2025-02-17 DOI: 10.32614/CRAN.package.nlmixr2extra Author: Matthew Fidler [aut, cre], Vipul Mann [aut], Vishal Sarsani [aut], Christian Bartels [ctb], Bill Denney [aut] Maintainer: Matthew Fidler <matthew.fidler at gmail.com> BugReports: https://github.com/nlmixr2/nlmixr2extra/issues/ License: GPL (≥ 3) URL: https://nlmixr2.github.io/nlmixr2extra/, https://github.com/nlmixr2/nlmixr2extra/ NeedsCompilation: yes Citation: nlmixr2extra citation info Materials: README, NEWS CRAN checks: nlmixr2extra results Documentation: Downloads: Reverse dependencies: Linking:Please use the canonical form https://CRAN.R-project.org/package=nlmixr2extra to link to this page.
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