Implements Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints and longitudinal efficacy measure from multiple treatment cycles. The package provides flags to fit a variety of model-based phase I design, including 1 stage models with or without individualized dose modification, 3-stage models with or without individualized dose modification, etc. Functions are provided to recommend dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.
Version: 1.0.2 Depends: R (≥ 3.0.0), coda (≥ 0.13), ggplot2, stats Imports: rjags, arrayhelpers, MASS, reshape2, plyr, dplyr, RColorBrewer, gridExtra, kableExtra, knitr Published: 2020-03-09 DOI: 10.32614/CRAN.package.phase1PRMD Author: Lu Zhang, Jun Yin Maintainer: Lu Zhang <luzhangstat at gmail.com> License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] NeedsCompilation: no SystemRequirements: JAGS (http://mcmc-jags.sourceforge.net) Materials: README NEWS CRAN checks: phase1PRMD results Documentation: Downloads: Linking:Please use the canonical form https://CRAN.R-project.org/package=phase1PRMD to link to this page.
RetroSearch is an open source project built by @garambo | Open a GitHub Issue
Search and Browse the WWW like it's 1997 | Search results from DuckDuckGo
HTML:
3.2
| Encoding:
UTF-8
| Version:
0.7.4