The tcplfit2 R package performs basic concentration-response curve fitting. The original tcplFit() function in the tcpl R package performed basic concentration-response curvefitting to 3 models. With tcplfit2, the core tcpl concentration-response functionality has been expanded to process diverse high-throughput screen (HTS) data generated at the US Environmental Protection Agency, including targeted ToxCast, high-throughput transcriptomics (HTTr) and high-throughput phenotypic profiling (HTPP). tcplfit2 can be used independently to support analysis for diverse chemical screening efforts.
Version: 0.1.9 Depends: R (≥ 3.5.0) Imports: stats, methods, numDeriv, RColorBrewer, stringr, reshape2, ggplot2 (≥ 3.5.0) Suggests: knitr, rmarkdown, stringi, DT, data.table, tcpl, prettydoc, testthat (≥ 3.0.0), here, htmlTable, tidyr, dplyr, gridExtra, rmdformats Published: 2025-07-23 DOI: 10.32614/CRAN.package.tcplfit2 Author: Thomas Sheffield [aut], Jason Brown [ctb], Sarah E. Davidson-Fritz [ctb], Madison Feshuk [ctb, cre], Lindsay Knupp [ctb], Zhihui Zhao [ctb], Richard S Judson [ctb], Katie Paul Friedman [ctb] Maintainer: Madison Feshuk <feshuk.madison at epa.gov> BugReports: https://github.com/USEPA/CompTox-ToxCast-tcplFit2/issues License: MIT + file LICENSE URL: https://github.com/USEPA/CompTox-ToxCast-tcplFit2 NeedsCompilation: no Materials: README, NEWS CRAN checks: tcplfit2 resultsRetroSearch is an open source project built by @garambo | Open a GitHub Issue
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