Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).
Version: 3.0.4 Depends: nlmixr2data, R (≥ 4.0) Imports: backports, checkmate, cli, graphics, knitr, lbfgsb3c, lotri, magrittr, Matrix, methods, minqa, n1qn1 (≥ 6.0.1-12), nlme, Rcpp, rex, rxode2 (≥ 3.0.0), stats, symengine, utils LinkingTo: BH, n1qn1 (≥ 6.0.1-12), lbfgsb3c (≥ 2024-3.5), lotri (≥ 0.5.0), Rcpp, RcppArmadillo (≥ 0.11.2.3.1), RcppEigen, rxode2 (≥ 3.0.0) Suggests: broom.mixed, crayon, data.table, devtools, digest, dplyr (≥ 1.1.0), generics, nloptr, qs, sys, testthat, tibble, withr, xgxr, sfsmisc, minpack.lm, remotes Published: 2025-02-19 DOI: 10.32614/CRAN.package.nlmixr2est Author: Matthew Fidler [aut, cre], Yuan Xiong [aut], Rik Schoemaker [aut], Justin Wilkins [aut], Wenping Wang [aut], Robert Leary [ctb], Mason McComb [ctb], Vipul Mann [aut], Mirjam Trame [ctb], Mahmoud Abdelwahab [ctb], Teun Post [ctb], Richard Hooijmaijers [aut], Hadley Wickham [ctb], Dirk Eddelbuettel [cph], Johannes Pfeifer [ctb], Robert B. Schnabel [ctb], Elizabeth Eskow [ctb], Emmanuelle Comets [ctb], Audrey Lavenu [ctb], Marc Lavielle [ctb], David Ardia [cph], Katharine Mullen [cph], Ben Goodrich [ctb] Maintainer: Matthew Fidler <matthew.fidler at gmail.com> License: GPL (≥ 3) URL: https://github.com/nlmixr2/nlmixr2est, https://nlmixr2.github.io/nlmixr2est/ NeedsCompilation: yes Language: en-US Citation: nlmixr2est citation info Materials: NEWS CRAN checks: nlmixr2est results Documentation: Downloads: Reverse dependencies: Linking:Please use the canonical form https://CRAN.R-project.org/package=nlmixr2est to link to this page.
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