A user-friendly workflow for simulating circadian clock gene networks. Despite decades of advances in modeling circadian clock dynamics, the lack of accessible tools for reproducible simulation workflows hinders the integration of computational modeling with experimental studies. âclockSimâ addresses this gap by providing models and helper functions with step-by-step vignettes. This package opens up system-level exploration of the circadian clock to wet-lab experimentalists, and future development will include additional clock architectures and other gene circuit models. Currently implemented models are based on Leloup and Goldbeter (1998) doi:10.1177/074873098128999934.
InstallationTo install current CRAN version of clockSim:
install.packages("clockSim")You can install the development version of clockSim from GitHub with:
# install.packages("pak")
pak::pak("yeyuan98/clockSim")Refer to the package vignettes on example workflows on circadian clock simulation.
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