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CRAN: Package LTFGRS

LTFGRS: Implementation of Several Phenotype-Based Family Genetic Risk Scores

Implementation of several phenotype-based family genetic risk scores with unified input data and data preparation functions to help facilitate the required data preparation and management. The implemented family genetic risk scores are the extended liability threshold model conditional on family history (LT-FH++) from Pedersen (2022) <doi:10.1016/j.ajhg.2022.01.009> and Pedersen (2023) <https://www.nature.com/articles/s41467-023-41210-z>, Pearson-Aitken Family Genetic Risk Scores (PA-FGRS) from Krebs (2024) <doi:10.1016/j.ajhg.2024.09.009>, and family genetic risk score by Kendler (2021) <doi:10.1001/jamapsychiatry.2021.0336>.

Version: 1.0.0 Imports: batchmeans, dplyr, future.apply, future, lubridate, purrr, Rcpp, rlang, stats, stringr, tibble, tmvtnorm, tidyselect, igraph, xgboost, tidyr LinkingTo: Rcpp Suggests: knitr, rmarkdown, testthat (≥ 3.0.0), MASS Published: 2025-07-07 DOI: 10.32614/CRAN.package.LTFGRS Author: Emil Michael Pedersen [aut, cre], Jette Steinbach [aut], Lucas Rasmussen [ctb], Morten Dybdahl Krebs [aut] Maintainer: Emil Michael Pedersen <emp at ph.au.dk> BugReports: https://github.com/EmilMiP/LTFGRS/issues License: GPL (≥ 3) URL: https://emilmip.github.io/LTFGRS/ NeedsCompilation: yes Language: en-GB Materials: README NEWS CRAN checks: LTFGRS results Documentation: Downloads: Linking:

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